Nitric oxide-mediated inhibition of caspase-dependent T lymphocyte proliferation
نویسندگان
چکیده
منابع مشابه
Nitric oxide-mediated inhibition of caspase-dependent T lymphocyte proliferation.
Nitric oxide (NO), a pleiotropic signaling molecule produced at sites of inflammation, is a powerful inhibitor of lymphocyte proliferation. Caspases, central effector proteases in apoptosis, have recently been implicated as critical mediators of T cell activation. We and others have shown that NO can inhibit caspases by S-nitrosylation, which is reversible by the reducing agent dithiothreitol (...
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Objective(s): Despite several proposed mechanisms for the pathophysiology of cardiorenal syndrome (CRS), the exact mechanism remains unclear. Nitrosative stress has been argued as a key mechanism recently. Nebivolol is a beta-blocker with nitric oxide (NO)-releasing effect. In the present study, NO-mediated effects of two different treatment regimes of nebivolol in CRS...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2003
ISSN: 0741-5400
DOI: 10.1189/jlb.0602293